همایش ملی بیوانفورماتیک ایران

صفحه اصلی / 4th international edition and 13th Iranian Conference on Bioinformatics

Discovery of effective markers in the severity of the disease in the genome of Iranian patients with covid-19 and introduction of an effective plant in controlling the severity of the disease

نویسندگان :

Fariba Esmaeili¹ Dariush Salimi²

1- دانشگاه زنجان 2- دانشگاه زنجان

کلمات کلیدی :

miRNAs،interactions،genetic sequence،effective plant،viruses

چکیده :

There are various miRNAs in the human body and today it has been confirmed that human miRNAs are effective in regulating the expression of viral genes and can be used to limit the infection caused by the virus. Also, nowadays, the transfer of plant miRNAs to the human body through their oral consumption or other methods is obvious, and therefore, one of the effects of medicinal plants in curing diseases can be the result of the function of this genetic structure of plants in the human body. In this study, the information related to the genetic sequence of viruses belonging to corona patients in the population of 110 Iranian patients, including 55 with high severity of the disease and 55 with low severity, was used. After extracting and storing the information of different human miRNAs, unique miRNAs (hsa-miR-548bb and hsa-miR-548b p, hsa-miR-548ay and hsa-miR-548aq) were present in patients with low severity. In the structure of the virus, a target sequence was identified for them and they were introduced as important markers affecting the severity of the disease. This finding indicates that the presence of the target sequence of these miRNAs in the genome of viruses extracted from patients with low severity indicates the possibility of their effect on the expression of viral genes and ultimately limiting the amount of virus replication of the severity of the disease. Since the use of medicinal plants to control and control the corona virus has less side effects and their availability is more for patients all over the world, in this research, with the aim of introducing an effective plant to control the corona virus, to investigate the interactions of human target sequences and miRNA The results of ten types of plants along with the miRNAs extracted in the previous step that were related to the severity of the disease were performed using the mintRULS method. The output of the mintRULS model in predicting possible interactions showed that miRNAs of the cinnamon plant had the most interactions with the target sequences in the corona virus, which were similar to the regions identified in the previous step.