0% Complete
صفحه اصلی
/
4th international edition and 13th Iranian Conference on Bioinformatics
Identification of Therapeutic Biomarkers in Patients with Rheumatoid Arthritis Treated with Methotrexate
نویسندگان :
Narges Yaghoobi
1
Tannaz Araei
2
Sara Abedi
3
Mohsen Goharinia
4
Mohammad Mehdi Naghizadeh
5
1- دانشگاه علوم پزشکی فسا
2- دانشگاه علوم پزشکی فسا
3- دانشگاه علوم پزشکی فسا
4- دانشگاه علوم پزشکی فسا
5- دانشگاه علوم پزشکی فسا
کلمات کلیدی :
miRNA،Rheumatoid Arthritis،Methotrexate،Regulatory network
چکیده :
Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and joint destruction, significantly impacting patients' quality of life [1]. Methotrexate (MTX) remains the cornerstone of RA treatment; however, variability in therapeutic response presents a challenge, prompting researchers to explore molecular predictive biomarkers to optimize patient outcomes [2]. non-coding RNAs, such as miRNAs have recently gained attention due to their regulatory roles in gene expression [3]. Emerging evidence suggests that non-coding RNAs play crucial roles in autoimmune diseases, including RA. Gene expression profiles (GSE45867) were downloaded from the Gene Expression Omnibus. Differentially expressed genes and miRNAs were identified using the GEO2R analysis. Enrichr was used to obtain the pathway and biological process. miRTarbase database were used to receive miRNAs. The miRNA-mRNA interaction was reconstructed with Cytoscape software. Functional enrichment analysis identified several pathways and biological processes associated with PIP, including Interferon Signaling, Immunoregulatory Interactions between Lymphoid and Non-Lymphoid Cells, Signaling by Interleukins, Transforming Growth Factor Beta (TGF-β) Family Signaling, and Neutrophil Degranulation. The results of this study showed that miR-124-3p, miR-101-3p, miR-16-5p and miR-26b-5p have most important regulatory roles. This study identifies that these miRNAs may serve as therapeutic biomarkers in predicting the response to methotrexate treatment.
لیست مقالات
لیست مقالات بایگانی شده
Assessment of TP53 Gene Mutations by Bioinformatic tools and Their Impact on Tumor Suppressor Function
Hirad Akhlaghi - Mehri Khatami
Morphine pathway analysis with bioinformatics
Nazila Bagheri - Alireza Tarinejad - Mohammad Majidi - Karim Hassanpour
Graphene Oxide Nanosheets as Drug Carriers for Erdafitinib in a Targeted Drug Delivery System: A Cutting-Edge Approach to Cancer Therapy
Hooriye Yahyaei - Nahid Shajari - Amirreza Saeni - Ahmadreza Saeni
Tailoring Stability of Keratinocyte Growth Factor Variants for Effective Wound Healing in Acidic Conditions
Mansoureh Shahbazi Dastjerdeh - Mohammadtaghi Borjian Boroujeni
A Computational Approach to Identify Potent Inhibitors of Janus Kinase 1 from Natural Products: Structure-Based High-Throughput Virtual Screening and LightGBM Classifier.
Parisa Valipour
Reconstruction and analysis of lncRNA-miRNA-mRNA ceRNA network to explore the potential biomarkers for colorectal cancer
Sara Nafei Milani - Negar Sadat Soleimani Zakeri - Habib MotieGhader
Machine-learning based biomarker discovery for Striga resistance in sorghum
Leyla Nazari - Afshar Estakhr
Enzybiotic Activity in Marine Bacteria: Unveiling Cooperative and Competitive Dynamics for Antimicrobial Potential
Mohammad Reza Zabihi - Arad Ariaeenejad - Arman Hasannejad - Donya Afshar Jahanshahi - Shohreh Ariaeenejad - Kaveh Kavousi
Development of Novel Cellulose Crystal-Hyaluronic Acid Anti-Cancer Carriers for Targeting
Yeganeh Abbasian Bajgiran - Maryam Azimzadeh Irani
Investigating the Potential of Natural Small Molecules as BDNF Mimetics for Neurodegenerative Disease Treatment: A Molecular Docking Study with TrkB Receptor
Sevil Babashpour - Dina Morshedi - Farhang Aliakbari
بیشتر
ثمین همایش، سامانه مدیریت کنفرانس ها و جشنواره ها - نگارش 42.7.0