0% Complete
صفحه اصلی
/
4th international edition and 13th Iranian Conference on Bioinformatics
Genetic Insights into Osteosarcoma: Implications for Targeted Drug Therapy
نویسندگان :
MalihehSadat Atri
1
Amirhossein Soltani
2
Mohammadhossein Abedi
3
1- دانشگاه مازندران
2- دانشگاه مازندران
3- دانشگاه مازندران
کلمات کلیدی :
Osteosarcoma،Targeted Therapy،GeneMANIA،Bioinformatics analysis
چکیده :
Osteosarcoma is a type of bone cancer that primarily affects the long bones, such as those in the arms and legs, but it can also occur in other bones. It is most commonly diagnosed in adolescents and young adults, typically between the ages of 10 and 20, although it can occur at any age. By exploring the genetic landscape of Osteosarcoma, this research aimed to compile an extensive list of genes associated with Osteosarcoma, then identify the critical genes that drive this condition and to elucidate their significant roles in its progression. To achieve this, we collected Osteosarcoma-related genes by thoroughly reviewing the literature available on PubMed, specially selecting studies that showed a significant correlation between genes and Osteosarcoma (p-value < 0.05). In addition, we used databases such as My Cancer Genome Database, Cancer Genetics Web Database and osteosarcoma-db.uni-muenster.de. GeneMANIA (http://www.genemania.org) is a flexible, user-friendly web interface for generating hypotheses about gene function, analyzing gene lists and prioritizing genes for functional assays. Utilizing GeneMANIA Cytoscape software along with the CytoHubba plugin, we investigated the biological connections among these genes, visualizing a comprehensive network that highlights their interrelationships. Among all the osteosarcoma related genes collected, 168 genes were linked to drugs. These drugs included VX-702, Minocycline, MP470, Arsenic trioxide, Purvalanol, Flavopiridol, ABT-263, Olomoucine, SB-681323, SCIO-469. Among these drugs, Minocycline can affect ILB1-CYCS- CASP1- VEGFA-MMP9- CASP3- ALOX5 genes, Arsenic trioxide can affect MAPK1-MAPK3- JUN-AKT1- CCND1- IKBKB- TXNRD1 genes and VX-702 drug have a significant relationship with IL6-IL1B-TNF-MAPK14 genes and can affect these genes. This analysis not only allows us to identify crucial genes but also to discover the most important drugs associated with the genes related to Osteosarcoma, providing a better understanding of gene function. As a result, even in the later stages of our work, we can find non-coding RNAs associated with the top genes in Osteosarcoma and study their effects on these genes. This study could lead to the prescription of drugs that target non-coding RNAs, effectively silencing the genes that contribute to cancer progression.
لیست مقالات
لیست مقالات بایگانی شده
Exploring Genetic Variability: A Bioinformatics Approach to Analyzing Reported SNPs in the cagA Gene of Helicobacter pylori
Aria Soltani
Identification of a natural specific inhibitor for Akt1 protein through molecular docking studies and evaluation of DFT calculations and molecular dynamics simulations
Forough Pakzadi - Yaghub Pazhang - Ebrahim Nemati-Kande
A Contrastive Learning Framework for Single-Cell Multi-Omics Data Integration
Amir Ebrahimi - Alireza Fotuhi Siahpirani - Hesam Montazeri
A Computational Approach to Identify Potent Inhibitors of Janus Kinase 1 from Natural Products: Structure-Based High-Throughput Virtual Screening and LightGBM Classifier.
Parisa Valipour
Exploring the anti-inflammatory potential of the silymarin against IL-17A: in silico molecular docking
Tooba Abdizadeh
Diagnosis of Diabetic Retinopathy with Fuzzy Technique and Deep Learning
Samaneh Noroozi - Sajad Haghzad Klidbary
Reconstruction and analysis of lncRNA-miRNA-mRNA ceRNA network to explore the potential biomarkers for colorectal cancer
Sara Nafei Milani - Negar Sadat Soleimani Zakeri - Habib MotieGhader
Machine Learning-Driven Discovery of JAK2 Inhibitors from ChEMBL Databank
Negar Abdolmaleki - Hamid Mahdiuni
Molecular Docking Study of Pyrazole Interaction with Bovine Serum Albumin (BSA): Insights from Drug-Protein Binding
Parisa Zallou - Yaghub Pazhang - Ebrahim Nemati-Kande
BIRC5: The Silent Architect of Tumor Persistence and Senescence in Hepatocellular Carcinoma
Amirhosein Farrokhzad - Maryam Kaboli - Elahe Hoseinnia - Elham Rismani - Massoud Vosough
بیشتر
ثمین همایش، سامانه مدیریت کنفرانس ها و جشنواره ها - نگارش 42.7.0