همایش ملی بیوانفورماتیک ایران

صفحه اصلی / 4th international edition and 13th Iranian Conference on Bioinformatics

Prediction of E8 mpox virus protein structure: a potential to design inhibitor

نویسندگان :

Mahsa Kazemi¹ Saeide Karimi² Maryam Kheirani nasab³ Maryam Kazemi⁴ Mahboobeh Nazari⁵

1- دانشگاه علم و فرهنگ تهران 2- دانشگاه علم و فرهنگ تهران 3- دانشگاه علم و فرهنگ تهران 4- دانشگاه علم و فرهنگ تهران 5- پژوهشگاه ابن سینا

کلمات کلیدی :

Monkeypox virus (MPXV)،viral structure،E8،structural prediction

چکیده :

The World Health Organization (WHO) has classified the Monkeypox outbreak as a public health emergency due to the absence of specific therapeutic interventions for the Monkeypox Virus (MPXV). This virus is classified as a rare zoonotic pathogen within the Orthopoxvirus genus of the Poxviridae family. The entry of MPXV into host cells involves several key proteins. This study aims to perform a structural analysis of the E8 envelope protein, which plays a crucial role in the virus's pathogenesis and its ability to bind to host cells.(Martínez-Fernández, Fernández-Quezada et al. 2023) (Das, Bhattarai et al. 2024) (Lu, Xing et al. 2023) To investigate the structural properties of the E8 protein, including its amino acid composition and domain structure, various bioinformatics tools were employed, such as InterPro, ProtPram, and PSIPRED. For modeling the E8 protein of Monkeypox Virus (MPXV), we utilized SWISS-MODEL, Robetta, and AlphaFold. Analysis of the generated models revealed that the AlphaFold model provided the most accurate representation of the E8 protein and may serve as a foundational framework for future drug design efforts..