0% Complete
صفحه اصلی
/
4th international edition and 13th Iranian Conference on Bioinformatics
Dissecting the impact of smoking on epigenetic mechanisms that influencing Lung cancer susceptibility
نویسندگان :
Mahboobeh Golchinpour
1
Alireza Fotuhi Siahpirani
2
1- Laboratory of Bioinformatics and Computational Genomics (LBCG), Department of Bioinformatics, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran
2- Laboratory of Bioinformatics and Computational Genomics (LBCG), Department of Bioinformatics, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran
کلمات کلیدی :
Gene Regulation،lung cancer susceptibility،differentially accessible regions
چکیده :
Epigenetic mechanisms play a crucial role in mediating the effects of environmental factors on cell fate and disease. One such environmental factor is smoking which is a major risk factor in lung cancer. To assess how smoking affect lung cancer susceptibility, we used a publicly available dataset (GSE241468), which examines the epigenetic landscapes and gene regulation in human lung cells by using multiome (transcriptome and chromatin accessibility) maps from 117,911 lung cells derived from 4 males and 4 females in each group of smokers and never-smokers (Long et al. 2024). Here, we reanalyzed this dataset, to identify differentially accessible regions (DARs) and differentially expressed genes (DEGs) between smokers and never-smokers. Seurat and Signac were used for preprocessing of the dataset. We then used a correlation-based approach for identifying candidate CREs in DARs and showed enrichment of binding motifs of transcription factors that are activated in these regions in response to smoking. By characterizing cell-type-specific CREs, our analysis showed that smoking-responsive genes predominantly exhibit cell-type-specific differential expression which contribute to lung cancer susceptibility. Results suggests that DARs contribute to augmented transcriptional responses under smoking conditions and affect lung cancer susceptibility. By linking these epigenetic alterations directly to smoking and identifying key target genes and cell types, our findings provide a map of the epigenetic landscape shaping lung cancer risk and open avenues for targeted interventions in these epigenetically altered pathways.
لیست مقالات
لیست مقالات بایگانی شده
Graphene Oxide Nanosheets as Drug Carriers for Erdafitinib in a Targeted Drug Delivery System: A Cutting-Edge Approach to Cancer Therapy
Hooriye Yahyaei - Nahid Shajari - Amirreza Saeni - Ahmadreza Saeni
Distribution and Allelic Diversity of Outer Membrane Proteins in Helicobacter pylori: Implications for Vaccine Development and Therapeutic Approach
Mohammadreza Najafi Disfani - Mahyar Abdi - Sarvin Rezvani Bafroyeh - SeyedehRomina Lavasani - Parastoo Saniee
Validation of Prognostic Biomarkers in Pancreatic Cancer Through Multi-Dataset Analysis and Pathway Enrichment
Ana Roohani - Somayeh Reiisi
Expansion and Sequencing of the DNA Code Used in the COVID-19 Vaccine Using Meta-Heuristic Algorithms
Ahmad Aliyari Boroujeni - Mohammadreza Parsayi - Hossein Rahmati
Development of a Multi-Epitope Vaccine Candidate for Brucella: An Immunoinformatics Approach to Achieve Cross-Protection
Zohre Sadeghi - Zahra Davoudi
Investigation and comparison of TYDC2 gene expression in different tissues (root, leaf, capsule and petal) of medicinal plant poppy (Papaver somniferum L.) in terms of bioinformatics
Nazila Bagheri - Alireza Tarinejad - Mohammad Majidi - Karim Hasanpour
Discovery of effective markers in the severity of the disease in the genome of Iranian patients with covid-19 and introduction of an effective plant in controlling the severity of the disease
Fariba Esmaeili - Dariush Salimi
Element-Specific Estimation of Background Mutation Rates in Whole Cancer Genomes Through Transfer Learning
ّFarideh Bahari - Reza Ahangari Cohan - Hesam Montazeri
Fully Convolutional Neural Networks for Volumetric Segmentation of Ultrasound Images: An Effective Tool for Automated Estimation of Fetal Head Circumference
Seyed Vahab Shojaedini - Mohammad Momenian
Phylogenetic Insights into Enzybiotic with Novel Properties
Arman Hasannejad - Arad Ariaeenejad - Donya Afshar Jahanshahi - Mohammad Reza Zabihi - Shohreh Ariaeenejad - Kaveh Kavousi
بیشتر
ثمین همایش، سامانه مدیریت کنفرانس ها و جشنواره ها - نگارش 42.7.0