همایش ملی بیوانفورماتیک ایران

صفحه اصلی / 4th international edition and 13th Iranian Conference on Bioinformatics

A dynamic co-expression approach reveals Gins2 as a potential upstream modulator of HNSCC metastasis

نویسندگان :

Nasibeh Khayer¹ Samira Shabani² Maryam Jalessi³ Mohammad Taghi Joghataei⁴ Frouzandeh Mahjoubi⁵

1- Iran University of Medical Sciences 2- 2National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran 3- Iran University of Medical Sciences 4- Iran University of Medical Sciences 5- 2National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran

کلمات کلیدی :

Head and neck squamous cell carcinoma،liquid association method،metastasis،PI3K/AKT/mTOR signaling pathway

چکیده :

Head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer that is notably associated with a high risk of lymph node metastasis, a major cause of cancer mortality. Current therapeutic options remain limited to surgery supplemented by radio- or chemotherapy; however, these interventions often result in high-grade toxicities. Distant metastasis significantly contributed to the poor prognosis and decreased survival rates. However, the underlying molecular mechanisms remain poorly understood. Disease-related “omics” data provide a comprehensive overview of gene relationships, helping to decode the complex molecular mechanisms involved. Interactions between biological molecules are complex and highly dynamic across various cellular conditions, making traditional co-expression methods inadequate for understanding these intricate relationships. In the present study, a novel three-way interaction approach was employed to uncover dynamic co-expression relationships underlying the metastatic nature of HNSCC. Subsequently, the biologically relevant triples from statistically significant ones were defined through gene set enrichment analysis and reconstruction of the gene regulatory network. Finally, the validity of biologically relevant triplets was assessed at the protein level. The results highlighted the “PI3K/AKT/mTOR (PAM) signaling pathway” as a disrupted pathway involved in the metastatic nature of HNSCC. Notably, Gins2, identified as a switch gene, along with the gene pair {Akt2, Anxa2}, formed a statistically significant and biologically relevant triplet. It suggests that Gins2 could serve as a potential upstream modulator in the PAM signaling pathway, playing a crucial role in the distant metastasis of HNSCC. In addition, survival analysis of significant switch genes indicated that two genes, C19orf33 and Usp13, may be especially important for prognostic purposes in HNSCC.

لیست مقالات

لیست مقالات بایگانی شده

Identification of Driver Genes in Glioblastoma Based on Single-Cell Gene Expression Data Using Integrated Pseudotime and Phylogenetic Analysis

Fateme Mirza-Abolhassani - Sobhan Ahmadian Moghadam - Fatemeh Zare-Mirakabad - Kaveh Kavousi

Comprehensive Analysis of DCLK Family Kinases in Gastrointestinal Cancers and Neoplastic Progression

Zahra Salehi - Leili Rejali - Moein Piroozkhah - Pooya Jalali - Ali Aghajani - Mahsa Saeedi Niyasar - Binazir Khanabadi - Amir Sadeghi - Ehsan Nazemalhossein Mojarad

Analysis of enrichment pathways and ontology of genes related to Feed efficiency in sheep

Mehre Mohammadnezhad - Mohsen Gholizadeh

Identification of potential RNA interference targets in bladder cancer through bioinformatics approaches

Sana Sajjadi - Mohammad ali Takhshid

Novel Potential Peripheral ECM Biomarkers for Prognosis and Therapeutic Approaches in Liver Cirrhosis Based on Microarray Analysis

Sorour Akrami - Masoud Vosough

Statistical Investigation on the Occurrence of Liquid-Liquid Phase Separation in Proteins Involved in Neurodegenerative Proteins

Pouya Alimohammadi - Saeed Emadi - Mahdi Vasighi

AI-Driven Discovery of Novel AChE Inhibitors for Alzheimer's Disease Treatment: Model Development, Molecular Docking, and MD Simulation

Ahmad Ebadi - Fatemeh Noori

Bioinformatics and computational Studies on Highly Conserved Neurocalcin Protein

Ali Eyvazi - Khosrow Khalifeh - Emran Heshmati

In Silico Analysis of the R410W Mutation in ZP1: Effects on Protein Stability and Interactions

Seyedeh Zahra Mousavi - Pegah Kouhi - Zeinab Rokhsattalab - Mehdi Totonchi

Molecular Investigation of Periplasmic Sensor Histidine Kinase Interactions in Regulating UV Shield Formation of Cyanobacteria Nostoc Sp

Maryam Eskafi - Maryam Azimzadeh Irani

بیشتر